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canonical pathway maps  (Metabase Inc)

 
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    Metabase Inc canonical pathway maps
    Canonical Pathway Maps, supplied by Metabase Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/canonical+pathway+maps/canonical+pathway+maps/pm31626963-83-5-10
    Average 90 stars, based on 1 article reviews
    canonical pathway maps - by Bioz Stars, 2026-10
    90/100 stars

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    Article Title: Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms
    Article Snippet: Here, causal networks were reconstructed using canonical pathway maps from the MetaBase resource, precisely the previously identified key pathways, since these maps contain experimentally validated interactions only and are structured the same way as a causal network.

    Article Title: Screening of kinase inhibitors downregulating PD-L1 expression via on/in cell quantitative immunoblots.
    Article Snippet: The interaction of programmed death-1 (PD-1) and it’s ligands (PD-L1)is an important immune checkpoint and blockade of PD-1/PD-L1 axis with antibodies against PD-L1 showed promising anti-tumor activity in clinical practice.. However, only a small percentage of patients can benefit from PD-L1 mAbs.. Small molecular kinase inhibitors have been widely used as antitumor drugs for many years, and several kinase inhibitors were recently reported to inhibit the expression of PD-L1.



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    canonical pathway maps  (Metabase Inc)
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    Metabase Inc canonical pathway maps
    Canonical Pathway Maps, supplied by Metabase Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/canonical+pathway+maps/canonical+pathway+maps/pm31626963-83-5-10
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    canonical cholesterol biosynthesis pathway map  (GeneGo Inc)
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    Canonical <t>cholesterol</t> <t>biosynthesis</t> pathway map in Theiler's murine encephalomyelitis. Transcriptional changes associated with cholesterol biosynthesis pathway in Theiler's murine encephalomyelitis virus (TMEV)‐infected mice in comparison with mock‐infected control mice, illustrated in the canonical cholesterol biosynthesis pathway map from Metacore™ database (Genego, St. Joseph, MI, USA). The bars labeled from one to four display the fold changes of significantly differentially regulated genes in TMEV‐infected animals (n = 6) compared with mock‐infected animals (n = 6) on 4 days post infection (dpi) employing pair‐wise Mann–Whitney U‐tests (P ≤ 0.05) (1 = 14 dpi; 2 = 42 dpi; 3 = 98 dpi; 4 = 196 dpi). The blue indicator scale of the bar marks the down‐regulation and displays a comparable measurement of the magnitude of the negative fold change. Green arrows = positive functional interaction; Z = catalysis; gray arrows = technical links; orange icons = enzymes; purple hexagons = generic compound; blue rectangle = normal process; gray rectangle = reaction. Acat1 = acetyl‐Coenzyme A acetyltransferase 1; Cyp51 = cytochrome P450, family 51; Dhcr24 = 24‐dehydrocholesterol reductase; Dhcr7 = 7‐dehydrocholesterol reductase; Ebp = phenylalkylamine Ca2+ antagonist (emopamil) binding protein; Fdft1 = farnesyl diphosphate farnesyl transferase 1; Fdps = farnesyl diphosphate synthetase; Ggps1 = geranylgeranyl diphosphate synthase 1; Hmgcr = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A reductase; Hmgcs1 = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A synthase 1; Idi1 = isopentenyl‐diphosphate delta isomerase; Idi2 = isopentenyl‐diphosphate delta isomerase 2; Lss = lanosterol synthase; Mvd = mevalonate (diphospho) decarboxylase; Mvk = mevalonate kinase; Nsdhl = NAD(P)‐dependent steroid dehydrogenase‐like; Pmvk = phosphomevalonate kinase; Sc4mol = sterol‐C4‐methyl oxidase‐like; Sc5d = sterol‐C5‐desaturase (fungal ERG3, delta‐5‐desaturase) homolog (Saccharomyces cerevisiae); Sqle = squalene epoxidase; Tm7sf2 = transmembrane 7 superfamily member 2.
    Canonical Cholesterol Biosynthesis Pathway Map, supplied by GeneGo Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/canonical+pathway+maps/canonical+cholesterol+biosynthesis+pathway+map/pmc08029487-273-26-34
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    canonical pathway maps  (GeneGo Inc)
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    Canonical <t>cholesterol</t> <t>biosynthesis</t> pathway map in Theiler's murine encephalomyelitis. Transcriptional changes associated with cholesterol biosynthesis pathway in Theiler's murine encephalomyelitis virus (TMEV)‐infected mice in comparison with mock‐infected control mice, illustrated in the canonical cholesterol biosynthesis pathway map from Metacore™ database (Genego, St. Joseph, MI, USA). The bars labeled from one to four display the fold changes of significantly differentially regulated genes in TMEV‐infected animals (n = 6) compared with mock‐infected animals (n = 6) on 4 days post infection (dpi) employing pair‐wise Mann–Whitney U‐tests (P ≤ 0.05) (1 = 14 dpi; 2 = 42 dpi; 3 = 98 dpi; 4 = 196 dpi). The blue indicator scale of the bar marks the down‐regulation and displays a comparable measurement of the magnitude of the negative fold change. Green arrows = positive functional interaction; Z = catalysis; gray arrows = technical links; orange icons = enzymes; purple hexagons = generic compound; blue rectangle = normal process; gray rectangle = reaction. Acat1 = acetyl‐Coenzyme A acetyltransferase 1; Cyp51 = cytochrome P450, family 51; Dhcr24 = 24‐dehydrocholesterol reductase; Dhcr7 = 7‐dehydrocholesterol reductase; Ebp = phenylalkylamine Ca2+ antagonist (emopamil) binding protein; Fdft1 = farnesyl diphosphate farnesyl transferase 1; Fdps = farnesyl diphosphate synthetase; Ggps1 = geranylgeranyl diphosphate synthase 1; Hmgcr = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A reductase; Hmgcs1 = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A synthase 1; Idi1 = isopentenyl‐diphosphate delta isomerase; Idi2 = isopentenyl‐diphosphate delta isomerase 2; Lss = lanosterol synthase; Mvd = mevalonate (diphospho) decarboxylase; Mvk = mevalonate kinase; Nsdhl = NAD(P)‐dependent steroid dehydrogenase‐like; Pmvk = phosphomevalonate kinase; Sc4mol = sterol‐C4‐methyl oxidase‐like; Sc5d = sterol‐C5‐desaturase (fungal ERG3, delta‐5‐desaturase) homolog (Saccharomyces cerevisiae); Sqle = squalene epoxidase; Tm7sf2 = transmembrane 7 superfamily member 2.
    Canonical Pathway Maps, supplied by GeneGo Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/canonical+pathway+maps/canonical+pathway+maps/10__1590_slash_1414___431x20154550-108-2-7
    Average 90 stars, based on 1 article reviews
    canonical pathway maps - by Bioz Stars, 2026-10
    90/100 stars
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    canonical pathway maps  (Thompson Reuters)
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    Canonical <t>cholesterol</t> <t>biosynthesis</t> pathway map in Theiler's murine encephalomyelitis. Transcriptional changes associated with cholesterol biosynthesis pathway in Theiler's murine encephalomyelitis virus (TMEV)‐infected mice in comparison with mock‐infected control mice, illustrated in the canonical cholesterol biosynthesis pathway map from Metacore™ database (Genego, St. Joseph, MI, USA). The bars labeled from one to four display the fold changes of significantly differentially regulated genes in TMEV‐infected animals (n = 6) compared with mock‐infected animals (n = 6) on 4 days post infection (dpi) employing pair‐wise Mann–Whitney U‐tests (P ≤ 0.05) (1 = 14 dpi; 2 = 42 dpi; 3 = 98 dpi; 4 = 196 dpi). The blue indicator scale of the bar marks the down‐regulation and displays a comparable measurement of the magnitude of the negative fold change. Green arrows = positive functional interaction; Z = catalysis; gray arrows = technical links; orange icons = enzymes; purple hexagons = generic compound; blue rectangle = normal process; gray rectangle = reaction. Acat1 = acetyl‐Coenzyme A acetyltransferase 1; Cyp51 = cytochrome P450, family 51; Dhcr24 = 24‐dehydrocholesterol reductase; Dhcr7 = 7‐dehydrocholesterol reductase; Ebp = phenylalkylamine Ca2+ antagonist (emopamil) binding protein; Fdft1 = farnesyl diphosphate farnesyl transferase 1; Fdps = farnesyl diphosphate synthetase; Ggps1 = geranylgeranyl diphosphate synthase 1; Hmgcr = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A reductase; Hmgcs1 = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A synthase 1; Idi1 = isopentenyl‐diphosphate delta isomerase; Idi2 = isopentenyl‐diphosphate delta isomerase 2; Lss = lanosterol synthase; Mvd = mevalonate (diphospho) decarboxylase; Mvk = mevalonate kinase; Nsdhl = NAD(P)‐dependent steroid dehydrogenase‐like; Pmvk = phosphomevalonate kinase; Sc4mol = sterol‐C4‐methyl oxidase‐like; Sc5d = sterol‐C5‐desaturase (fungal ERG3, delta‐5‐desaturase) homolog (Saccharomyces cerevisiae); Sqle = squalene epoxidase; Tm7sf2 = transmembrane 7 superfamily member 2.
    Canonical Pathway Maps, supplied by Thompson Reuters, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/canonical+pathway+maps/canonical+pathway+maps/pm25164976-95-7-16
    Average 90 stars, based on 1 article reviews
    canonical pathway maps - by Bioz Stars, 2026-10
    90/100 stars
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    canonical pathway maps (genego maps)  (GeneGo Inc)
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    GeneGo Inc canonical pathway maps (genego maps)
    Canonical <t>cholesterol</t> <t>biosynthesis</t> pathway map in Theiler's murine encephalomyelitis. Transcriptional changes associated with cholesterol biosynthesis pathway in Theiler's murine encephalomyelitis virus (TMEV)‐infected mice in comparison with mock‐infected control mice, illustrated in the canonical cholesterol biosynthesis pathway map from Metacore™ database (Genego, St. Joseph, MI, USA). The bars labeled from one to four display the fold changes of significantly differentially regulated genes in TMEV‐infected animals (n = 6) compared with mock‐infected animals (n = 6) on 4 days post infection (dpi) employing pair‐wise Mann–Whitney U‐tests (P ≤ 0.05) (1 = 14 dpi; 2 = 42 dpi; 3 = 98 dpi; 4 = 196 dpi). The blue indicator scale of the bar marks the down‐regulation and displays a comparable measurement of the magnitude of the negative fold change. Green arrows = positive functional interaction; Z = catalysis; gray arrows = technical links; orange icons = enzymes; purple hexagons = generic compound; blue rectangle = normal process; gray rectangle = reaction. Acat1 = acetyl‐Coenzyme A acetyltransferase 1; Cyp51 = cytochrome P450, family 51; Dhcr24 = 24‐dehydrocholesterol reductase; Dhcr7 = 7‐dehydrocholesterol reductase; Ebp = phenylalkylamine Ca2+ antagonist (emopamil) binding protein; Fdft1 = farnesyl diphosphate farnesyl transferase 1; Fdps = farnesyl diphosphate synthetase; Ggps1 = geranylgeranyl diphosphate synthase 1; Hmgcr = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A reductase; Hmgcs1 = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A synthase 1; Idi1 = isopentenyl‐diphosphate delta isomerase; Idi2 = isopentenyl‐diphosphate delta isomerase 2; Lss = lanosterol synthase; Mvd = mevalonate (diphospho) decarboxylase; Mvk = mevalonate kinase; Nsdhl = NAD(P)‐dependent steroid dehydrogenase‐like; Pmvk = phosphomevalonate kinase; Sc4mol = sterol‐C4‐methyl oxidase‐like; Sc5d = sterol‐C5‐desaturase (fungal ERG3, delta‐5‐desaturase) homolog (Saccharomyces cerevisiae); Sqle = squalene epoxidase; Tm7sf2 = transmembrane 7 superfamily member 2.
    Canonical Pathway Maps (Genego Maps), supplied by GeneGo Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/canonical+pathway+maps/canonical+pathway+maps/pmc04310925-52-23-26
    Average 90 stars, based on 1 article reviews
    canonical pathway maps (genego maps) - by Bioz Stars, 2026-10
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    Canonical cholesterol biosynthesis pathway map in Theiler's murine encephalomyelitis. Transcriptional changes associated with cholesterol biosynthesis pathway in Theiler's murine encephalomyelitis virus (TMEV)‐infected mice in comparison with mock‐infected control mice, illustrated in the canonical cholesterol biosynthesis pathway map from Metacore™ database (Genego, St. Joseph, MI, USA). The bars labeled from one to four display the fold changes of significantly differentially regulated genes in TMEV‐infected animals (n = 6) compared with mock‐infected animals (n = 6) on 4 days post infection (dpi) employing pair‐wise Mann–Whitney U‐tests (P ≤ 0.05) (1 = 14 dpi; 2 = 42 dpi; 3 = 98 dpi; 4 = 196 dpi). The blue indicator scale of the bar marks the down‐regulation and displays a comparable measurement of the magnitude of the negative fold change. Green arrows = positive functional interaction; Z = catalysis; gray arrows = technical links; orange icons = enzymes; purple hexagons = generic compound; blue rectangle = normal process; gray rectangle = reaction. Acat1 = acetyl‐Coenzyme A acetyltransferase 1; Cyp51 = cytochrome P450, family 51; Dhcr24 = 24‐dehydrocholesterol reductase; Dhcr7 = 7‐dehydrocholesterol reductase; Ebp = phenylalkylamine Ca2+ antagonist (emopamil) binding protein; Fdft1 = farnesyl diphosphate farnesyl transferase 1; Fdps = farnesyl diphosphate synthetase; Ggps1 = geranylgeranyl diphosphate synthase 1; Hmgcr = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A reductase; Hmgcs1 = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A synthase 1; Idi1 = isopentenyl‐diphosphate delta isomerase; Idi2 = isopentenyl‐diphosphate delta isomerase 2; Lss = lanosterol synthase; Mvd = mevalonate (diphospho) decarboxylase; Mvk = mevalonate kinase; Nsdhl = NAD(P)‐dependent steroid dehydrogenase‐like; Pmvk = phosphomevalonate kinase; Sc4mol = sterol‐C4‐methyl oxidase‐like; Sc5d = sterol‐C5‐desaturase (fungal ERG3, delta‐5‐desaturase) homolog (Saccharomyces cerevisiae); Sqle = squalene epoxidase; Tm7sf2 = transmembrane 7 superfamily member 2.

    Journal: Brain Pathology

    Article Title: Central Nervous System Demyelination and Remyelination is Independent from Systemic Cholesterol Level in T heiler's Murine Encephalomyelitis

    doi: 10.1111/bpa.12266

    Figure Lengend Snippet: Canonical cholesterol biosynthesis pathway map in Theiler's murine encephalomyelitis. Transcriptional changes associated with cholesterol biosynthesis pathway in Theiler's murine encephalomyelitis virus (TMEV)‐infected mice in comparison with mock‐infected control mice, illustrated in the canonical cholesterol biosynthesis pathway map from Metacore™ database (Genego, St. Joseph, MI, USA). The bars labeled from one to four display the fold changes of significantly differentially regulated genes in TMEV‐infected animals (n = 6) compared with mock‐infected animals (n = 6) on 4 days post infection (dpi) employing pair‐wise Mann–Whitney U‐tests (P ≤ 0.05) (1 = 14 dpi; 2 = 42 dpi; 3 = 98 dpi; 4 = 196 dpi). The blue indicator scale of the bar marks the down‐regulation and displays a comparable measurement of the magnitude of the negative fold change. Green arrows = positive functional interaction; Z = catalysis; gray arrows = technical links; orange icons = enzymes; purple hexagons = generic compound; blue rectangle = normal process; gray rectangle = reaction. Acat1 = acetyl‐Coenzyme A acetyltransferase 1; Cyp51 = cytochrome P450, family 51; Dhcr24 = 24‐dehydrocholesterol reductase; Dhcr7 = 7‐dehydrocholesterol reductase; Ebp = phenylalkylamine Ca2+ antagonist (emopamil) binding protein; Fdft1 = farnesyl diphosphate farnesyl transferase 1; Fdps = farnesyl diphosphate synthetase; Ggps1 = geranylgeranyl diphosphate synthase 1; Hmgcr = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A reductase; Hmgcs1 = 3‐hydroxy‐3‐methylglutaryl‐Coenzyme A synthase 1; Idi1 = isopentenyl‐diphosphate delta isomerase; Idi2 = isopentenyl‐diphosphate delta isomerase 2; Lss = lanosterol synthase; Mvd = mevalonate (diphospho) decarboxylase; Mvk = mevalonate kinase; Nsdhl = NAD(P)‐dependent steroid dehydrogenase‐like; Pmvk = phosphomevalonate kinase; Sc4mol = sterol‐C4‐methyl oxidase‐like; Sc5d = sterol‐C5‐desaturase (fungal ERG3, delta‐5‐desaturase) homolog (Saccharomyces cerevisiae); Sqle = squalene epoxidase; Tm7sf2 = transmembrane 7 superfamily member 2.

    Article Snippet: Transcriptional changes associated with cholesterol biosynthesis pathway in T heiler's murine encephalomyelitis virus ( TMEV )‐infected mice in comparison with mock‐infected control mice, illustrated in the canonical cholesterol biosynthesis pathway map from MetacoreTM database (Genego, S t. J oseph, MI, USA ).

    Techniques: Virus, Infection, Comparison, Control, Labeling, MANN-WHITNEY, Functional Assay, Binding Assay